Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 54,615 bioRxiv papers from 252,242 authors.

Investigation of the cellular reprogramming phenomenon referred to as stimulus-triggered acquisition of pluripotency (STAP)

By Hitoshi Niwa

Posted 28 Sep 2015
bioRxiv DOI: 10.1101/027730 (published DOI: 10.1038/srep28003)

In January 2014, it was reported that strong external stimuli, such as a transient low-pH stressor, was capable of inducing the reprogramming of mammalian somatic cells, resulting in the generation of pluripotent cells (Obokata et al. 2014a, b). This cellular reprograming event was designated 'stimulus-triggered acquisition of pluripotency' (STAP) by the authors of these reports. However, after multiple instances of scientific misconduct in the handling and presentation of the data were brought to light, both reports were retracted. To investigate the actual scientific significance of the purported STAP phenomenon, we sought to repeat the original experiments based on the methods presented in the retracted manuscripts and other relevant information. As a result, we have concluded that the STAP phenomenon as described in the original studies is not reproducible.

Download data

  • Downloaded 9,611 times
  • Download rankings, all-time:
    • Site-wide: 101 out of 54,615
    • In cell biology: 5 out of 2,582
  • Year to date:
    • Site-wide: 25,895 out of 54,615
  • Since beginning of last month:
    • Site-wide: 16,844 out of 54,615

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide

Sign up for the Rxivist weekly newsletter! (Click here for more details.)