Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 67,466 bioRxiv papers from 297,269 authors.
Cell shape regulates subcellular organelle location to control short-term Ca2+ signal dynamics in VSMC
The shape of cell is intimately connected to its function; however, we do not fully understand the underlying mechanism by which global shape regulates cell functions. Here, using a combination of theory, experiments and simulation, we investigated how global cell curvature can affect numerous subcellular activities and organization to control signal flow needed for phenotypic function. We find that global cell curvature regulates organelle location, inter-organelle distances and differential distribution of receptors in the plasma membrane. A combination of these factors leads to the modulation of signals transduced by the M3 muscarinic receptor/Gq/PLCβ pathway at the plasma membrane, amplifying Ca2+ dynamics in the cytoplasm and the nucleus as determined by increased activity of myosin light chain kinase in the cytoplasm and enhanced nuclear localization of the transcription factor NFAT. Taken together, our observations show a systems level phenomenon whereby global cell curvature affects subcellular organization and signaling to enable expression of phenotype.
- Downloaded 780 times
- Download rankings, all-time:
- Site-wide: 11,544 out of 67,466
- In cell biology: 440 out of 3,280
- Year to date:
- Site-wide: 21,646 out of 67,466
- Since beginning of last month:
- Site-wide: 29,686 out of 67,466
Downloads over time
Distribution of downloads per paper, site-wide
- Top preprints of 2018
- Paper search
- Author leaderboards
- Overall metrics
- The API
- Email newsletter
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!