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Software tools for automated transmission electron microscopy

By Martin Schorb, Isabella Haberbosch, Wim J. H. Hagen, Yannick Schwab, David N Mastronarde

Posted 10 Aug 2018
bioRxiv DOI: 10.1101/389502 (published DOI: 10.1038/s41592-019-0396-9)

In the recent years, electron microscopy in the life sciences has witnessed increasing demand for high-throughput data collection in both structural and cellular biology. We present a combination of software tools that enable automated acquisition guided by image analysis for a wide variety of Transmission Electron Microscopy applications. Using these tools, we demonstrate dose-reduction in single particle cryo-EM experiments, fully automated acquisition of every single cell in a plastic section and automated targeting of features on serial sections for 3D volume imaging even across multiple grids.

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