The sequential changes occurring with cancer progression are now being harnessed with therapeutic intent. Yet, there is no understanding of the chemical thermodynamics of proteomic changes associated with cancer progression/ cancer stage. This manuscript reveals a strong correlation of a chemical thermodynamic measure (known as Gibbs free energy) of protein-protein interaction networks for several cancer types and 5-year overall survival and stage in patients with cancer. Earlier studies have linked degree entropy of signaling networks to patient survival data, but not with stage. It appears that Gibbs free energy is a more general metric and accounts better for the underlying energetic landscape of protein expression in cells, thus correlating with stage as well as survival. This is an especially timely finding because of improved ability to obtain and analyze genomic/ proteomic information from individual patients. Yet, at least at present, only candidate gene imaging (FISH or immunohistochemistry) can be used for entropy computations. With continually expanding use of genomic information in clinical medicine, there is an ever-increasing need to understand the thermodynamics of protein-protein interaction networks.
- Downloaded 1,640 times
- Download rankings, all-time:
- Site-wide: 13,409
- In cancer biology: 271
- Year to date:
- Site-wide: 53,809
- Since beginning of last month:
- Site-wide: 89,130
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!