Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 67,316 bioRxiv papers from 296,340 authors.
Depression is one of the most significant contributors to disability worldwide, yet its etiology is not well understood. Changes in blood lipid levels such as reduced cholesterol have long been suspected to be associated with depression and suicide. Here we performed a two-sample bi-directional MR analysis to investigate their causal relationship, based on large-scale GWAS summary statistics (N up to 188,577 and 480,359 for lipid and depression traits respectively). Five depression-related phenotypes were included, namely major depressive disorder (MDD), depressive symptoms (DS), longest duration and number of episodes of having low mood, and history of deliberate self-harm (DSH) or suicide. MR was conducted with several approaches including inverse-variance weighted, Egger regression and Generalized Summary-data-based MR (GSMR). We found that reduced low-density lipoprotein cholesterol (LDL-c) and total cholesterol (TC) were causally related to higher risks of MDD (OR for 1-SD decrease in LDL-c: 1.07, 95% CI 1.05-1.10, p= 3.15E-08; OR for 1-SD decrease in TC: 1.08, 95% CI 1.04-1.12, p=2.94E-04) and more prolonged depressed/low mood. Lower LDL-c was also found to be causally linked to more severe DS. In addition, we observed that lower levels of high-density lipoprotein cholesterol (HDL-c) was casually related to increased DS, as well as heightened risks of DSH or suicide (OR=2.17, CI: 1.40-3.39). As for triglycerides (TG), we observed positive causal associations with DS, number of episodes of low mood and risks of DSH or suicide (OR=1.58, CI: 1.16-2.17). We did not detect any significant associations when depression phenotypes were treated as the exposure. Taken together, the current study suggests a causal relationship between reduced cholesterol and raised TG with risks of depression and related phenotypes. Further studies on its mechanistic basis and the clinical effects of lipid-lowering therapies may be warranted.
- Downloaded 519 times
- Download rankings, all-time:
- Site-wide: 20,198 out of 67,351
- In genetics: 1,350 out of 3,786
- Year to date:
- Site-wide: 11,970 out of 67,351
- Since beginning of last month:
- Site-wide: 16,128 out of 67,351
Downloads over time
Distribution of downloads per paper, site-wide
- Top preprints of 2018
- Paper search
- Author leaderboards
- Overall metrics
- The API
- Email newsletter
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!