Rxivist logo

SARS-CoV-2 exposure in Norway rats (Rattus norvegicus) from New York City

By Yang Wang, Julianna Lenoch, Dennis Kohler, Thomas DeLiberto, Cynthia Tang, Tao Li, Yizhi Tao, Minhui Guan, Susan Compton, Caroline Jutta Zeiss, Jun Hang, Xiu-Feng Wan

Posted 21 Nov 2022
bioRxiv DOI: 10.1101/2022.11.18.517156

Millions of Norway rats (Rattus norvegicus) inhabit New York City (NYC), presenting the potential for transmission of SARS-CoV-2 from humans to rats and other wildlife. We evaluated SARS-CoV-2 exposure among 79 rats captured from NYC during the fall of 2021. Results showed that 13 of 79 rats (16.5%) tested IgG or IgM positive, and partial genomes of SARS-CoV-2 were recovered from four rats that were qRT-PCR positive. Using a virus challenge study, we also showed that Alpha, Delta, and Omicron variants can cause robust infections in wild-type Sprague Dawley (SD) rats, including high level replications in the upper and lower respiratory tracts and induction of both innate and adaptive immune responses. Additionally, the Delta variant resulted in the highest infectivity. In summary, our results indicated that rats are susceptible to infection with Alpha, Delta, and Omicron variants, and rats in the NYC municipal sewer systems have been exposed to SARS-CoV-2. Our findings highlight the potential risk of secondary zoonotic transmission from urban rats and the need for further monitoring of SARS-CoV-2 in those populations.

Download data

  • Downloaded 1,783 times
  • Download rankings, all-time:
    • Site-wide: 16,038
    • In microbiology: None
  • Year to date:
    • Site-wide: 2,767
  • Since beginning of last month:
    • Site-wide: 292

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

News