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IQGAP3 Overexpression Correlates with Poor Prognosis and Radiation Therapy Resistance in Breast Cancer
Background: IQ motif-containing GTPase activating protein 3, the latest found protein of IQGAP family, may act as a crucial factor in the process of cancer development and progression; its clinical value in breast cancer remains unestablished. Methods: IQGAP3 levels were detected by real-time PCR and western blotting . Protein expression of IQGAP3 was evaluated immunohistochemically in specimens of 257 breast cancer patients. We analyze the association between IQGAP3 expression and the clinical characters and prognosis. Results: There was significant upregulation of IQGAP3 in breast cancer cell lines and human tumor tissues at both the mRNA and protein level. 110/257 (42.8%) of archived paraffin embedded specimens had high protein expression of IQGAP3. High expression of IQGAP3 was significantly related to clinical stage (P=0.001), T category (P=0.002), N category (P=0.001), locoregional recurrence(P=0.002), distant metastasis (P=0.001), and vital status (P=0.001). IQGAP3 was an independent prognostic factor of the whole cohort breast cancer patients (P=0.003, P=0.001). IQGAP3 expression correlates with radiation therapy resistance and was an independent predictor for radiation therapy outcome. Conclusions: IQGAP3 may be a reliable novel biomarker of breast cancer.
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