Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 72,942 bioRxiv papers from 317,562 authors.

Continued evolution in cancers gives rise to intra-tumour heterogeneity (ITH), which is a major mechanism of therapeutic resistance and therefore an important clinical challenge. However, the extent, origin and drivers of ITH across cancer types are poorly understood. Here, we extensively characterise ITH across 2,778 cancer whole genome sequences from 36 cancer types. We demonstrate that nearly all tumours (95.1%) with sufficient sequencing depth contain evidence of recent subclonal expansions and most cancer types show clear signs of positive selection in both clonal and subclonal protein coding variants. We find distinctive subclonal patterns of driver gene mutations, fusions, structural variation and copy-number alterations across cancer types. Dynamic, tumour-type specific changes of mutational processes between subclonal expansions shape differences between clonal and subclonal events. Our results underline the importance of ITH and its drivers in tumour evolution and provide an unprecedented pan-cancer resource of extensively annotated subclonal events, laying a foundation for future cancer genomic studies.

Download data

• Downloaded 4,179 times
• Download rankings, all-time:
  • Site-wide: 702 out of 72,942
  • In cancer biology: 20 out of 2,494
• Year to date:
  • Site-wide: 1,485 out of 72,942
• Since beginning of last month:
  • Site-wide: 1,485 out of 72,942

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide