Neutral tumor evolution?
By
Maxime Tarabichi,
Inigo Martincorena,
Moritz Gerstung,
Armand M Leroi,
Florian Markowetz,
Paul T. Spellman,
Quaid D. Morris,
Ole Christian Lingjærde,
David C Wedge,
Peter Van Loo,
on behalf of the PCAWG Evolution and Heterogeneity Working Group
Posted 30 Jun 2017
bioRxiv DOI: 10.1101/158006
(published DOI: 10.1038/s41588-018-0258-x)
Williams et al. (Nat. Genet. 48:238-224, 2016) recently reported neutral tumor evolution in one third of 904 samples from The Cancer Genome Atlas. Here, we assess the reproducibility and validity of their method and the extent of positive selection in subclonal mutations across cancer types. Our results do not support observable neutral tumor evolution and uncover strong positive selection within subclonal mutations across cancers.
Download data
- Downloaded 2,091 times
- Download rankings, all-time:
- Site-wide: 8,322
- In cancer biology: 136
- Year to date:
- Site-wide: 110,551
- Since beginning of last month:
- Site-wide: None
Altmetric data
Downloads over time
Distribution of downloads per paper, site-wide
PanLingua
News
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!