Neutral tumor evolution?
By
Maxime Tarabichi,
Inigo Martincorena,
Moritz Gerstung,
Armand M Leroi,
Florian Markowetz,
Paul T. Spellman,
Quaid D. Morris,
Ole Christian Lingjærde,
David C Wedge,
Peter Van Loo,
on behalf of the PCAWG Evolution and Heterogeneity Working Group
Posted 30 Jun 2017
bioRxiv DOI: 10.1101/158006
(published DOI: 10.1038/s41588-018-0258-x)
Williams et al. (Nat. Genet. 48:238-224, 2016) recently reported neutral tumor evolution in one third of 904 samples from The Cancer Genome Atlas. Here, we assess the reproducibility and validity of their method and the extent of positive selection in subclonal mutations across cancer types. Our results do not support observable neutral tumor evolution and uncover strong positive selection within subclonal mutations across cancers.
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