Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 57,812 bioRxiv papers from 266,109 authors.

Inferring processes underlying B-cell repertoire diversity.

By Yuval Elhanati, Zachary Sethna, Quentin Marcou, Curtis G Callan, Thierry Mora, Aleksandra M Walczak

Posted 11 Feb 2015
bioRxiv DOI: 10.1101/015115 (published DOI: 10.1098/rstb.2014.0243)

We quantify the VDJ recombination and somatic hypermutation processes in human B-cells using probabilistic inference methods on high-throughput DNA sequence repertoires of human B-cell receptor heavy chains. Our analysis captures the statistical properties of the naive repertoire, first after its initial generation via VDJ recombination and then after selection for functionality. We also infer statistical properties of the somatic hypermutation machinery (exclusive of subsequent effects of selection). Our main results are the following: the B-cell repertoire is substantially more diverse than T-cell repertoires, due to longer junctional insertions; sequences that pass initial selection are distinguished by having a higher probability of being generated in a VDJ recombination event; somatic hypermutations have a non-uniform distribution along the V gene that is well explained by an independent site model for the sequence context around the hypermutation site.

Download data

  • Downloaded 496 times
  • Download rankings, all-time:
    • Site-wide: 17,787 out of 57,812
    • In immunology: 302 out of 1,387
  • Year to date:
    • Site-wide: 41,246 out of 57,812
  • Since beginning of last month:
    • Site-wide: 48,305 out of 57,812

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News