Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 54,982 bioRxiv papers from 253,713 authors.
High dimensional analyses of cells dissociated from cryopreserved synovial tissue
Laura T. Donlin,
Deepak A. Rao,
Mandy J. McGeachy,
Jason D. Turner,
David J. Lieb,
Thomas M. Eisenhaure,
Edward P Browne,
Alessandra B. Pernis,
Lionel B. Ivashkiv,
Susan M. Goodman,
William H. Robinson,
Paul J. Utz,
James A. Lederer,
Ellen M. Gravallese,
Brendan F. Boyce,
Peter K. Gregersen,
Gary S. Firestein,
Larry W. Moreland,
Vivian P. Bykerk,
David L. Boyle,
Michael B. Brenner,
Jennifer H. Anolik
Posted 19 Mar 2018
bioRxiv DOI: 10.1101/284844 (published DOI: 10.1186/s13075-018-1631-y)
Posted 19 Mar 2018
Background: Detailed molecular analyses of cells from rheumatoid arthritis (RA) synovium hold promise in identifying cellular phenotypes that drive tissue pathology and joint damage. The Accelerating Medicines Partnership (AMP) RA/SLE network aims to deconstruct autoimmune pathology by examining cells within target tissues through multiple high-dimensional assays. Robust standardized protocols need to be developed before cellular phenotypes at a single cell level can be effectively compared across patient samples.
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