Unperturbed Expression Bias of Imprinted Genes in Schizophrenia
Barbara K Lipska,
David A. Lewis,
Hardik R Shah,
Jessica S Johnson,
Joseph D. Buxbaum,
Lambertus L Klei,
Mette A. Peters,
Raquel E. Gur,
Solveig K. Sieberts,
Thanneer M Perumal,
Posted 24 May 2018
bioRxiv DOI: 10.1101/329748 (published DOI: 10.1038/s41467-018-04960-9)
Posted 24 May 2018
How gene expression correlates with schizophrenia across individuals is beginning to be examined through analyses of RNA-seq from post-mortem brains of individuals with disease and control brains. Here we focus on variation in allele-specific expression, following up on the CommonMind Consortium (CMC) RNA-seq experiments of nearly 600 human dorsolateral prefrontal cortex (DLPFC) samples. Analyzing the extent of allelic expression bias---a hallmark of imprinting---we find that the number of imprinted human genes is consistent with lower estimates (approx. 0.5% of all genes) and thus contradicts much higher estimates. Moreover, the handful of putatively imprinted genes are all in close genomic proximity to known imprinted genes. Joint analysis of the imprinted genes across hundreds of individuals allowed us to establish how allelic bias depends on various factors. We find that age and genetic ancestry have gene-specific, differential effect on allelic bias. In contrast, allelic bias appears to be independent of schizophrenia.
- Downloaded 249 times
- Download rankings, all-time:
- Site-wide: 108,439
- In genomics: 6,309
- Year to date:
- Site-wide: 140,595
- Since beginning of last month:
- Site-wide: 103,447
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!