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Higher contact among vaccinated can be a mechanism for negative vaccine effectiveness

By Korryn Bodner, Jesse Knight, Mackenzie A. Hamilton, Sharmistha Mishra

Posted 27 Apr 2022
medRxiv DOI: 10.1101/2022.04.25.22274266

Evidence from early observational studies suggested negative vaccine effectiveness for the SARS-CoV-2 Omicron variant. Using transmission modeling, we illustrated how increased contact between vaccinated individuals, vaccinated contact heterogeneity, paired with lower vaccine efficacies could produce negative measurements and how we can identify this mechanism via a key temporal signature.

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