Rxivist logo

US-align: Universal Structure Alignments of Proteins, Nucleic Acids, and Macromolecular Complexes

By CHENGXIN ZHANG, Morgan Shine, Anna Marie Pyle, Yang Zhang

Posted 18 Apr 2022
bioRxiv DOI: 10.1101/2022.04.18.488565

Structure comparison and alignment are of fundamental importance in structural biology studies. We developed the first universal platform, US-align, to uniformly align monomer and complex structures of different macromolecules (proteins, RNAs, and DNAs). The pipeline is built on a uniform TM-score objective function coupled with a heuristic alignment searching algorithm. Large-scale benchmarks demonstrated significant advantages of US-align over state-of-the-art methods in pairwise and multiple structure alignments of different molecules. Detailed analyses showed that the major advantage of US-align lies in the extensive optimization of the unified objective function powered by efficient heuristic search iterations, which significantly improve the accuracy and speed of the structural alignment process. Meanwhile, the universal protocol fusing different molecular and structural types helps facilitate the heterogeneous oligomer structure comparison and template-based protein-protein and protein-RNA/DNA docking.

Download data

  • Downloaded 558 times
  • Download rankings, all-time:
    • Site-wide: 88,070
    • In bioinformatics: 10,944
  • Year to date:
    • Site-wide: 8,941
  • Since beginning of last month:
    • Site-wide: 12,661

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

News