Rxivist logo

We performed a high time-resolution, longitudinal study of normal pregnancy development by measuring cell-free RNA (cfRNA) in blood from women during each week of pregnancy. Analysis of tissue-specific transcripts in these samples enabled us to follow fetal and placental development with high resolution and sensitivity, and also to detect gene-specific responses of the maternal immune system to pregnancy. We established a "clock" for normal pregnancy development and enabled a direct molecular approach to determine expected delivery dates with comparable accuracy to ultrasound, creating the basis for a portable, inexpensive fetal dating method. We also identified a related gene set that accurately discriminated women at risk for spontaneous preterm delivery up to two months in advance of labor, forming the basis of a potential screening test for risk of preterm delivery.

Download data

  • Downloaded 818 times
  • Download rankings, all-time:
    • Site-wide: 28,685
    • In bioengineering: 496
  • Year to date:
    • Site-wide: 92,115
  • Since beginning of last month:
    • Site-wide: 69,261

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide