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Serological responses and six-month trajectories to COVID-19 Comirnaty and Spikevax booster vaccine, September 2021 to January 2022, London, United Kingdom

By Georgina Ireland, Heather Whitaker, Shamez Ladhani, Frances Baawuah, Sathyvani Subbarao, Suzanne Elgohari, Alexandra Smith, Michelle O'Brien, Corinne Whillock, Oliver Martin, Paul Moss, Mary E Ramsay, Gayatri Amirthalingam, Kevin Brown

Posted 18 Feb 2022
medRxiv DOI: 10.1101/2022.02.17.22271126

In contrast to the increasing levels of high avidity S antibody measured by the Roche assay in the first 6 months following natural infection, marked waning is seen post 2 or 3 doses of vaccine. Although the kinetics differ between those with vaccine-induced immunity compared to those infected prior to vaccination (hybrid immunity), waning rates appear to be similar following 2 or 3 doses of vaccine. These data should allow countries to optimise the timing of future doses of vaccine.

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