Booster of mRNA-1273 Strengthens SARS-CoV-2 Omicron Neutralization
Stephen D. Schmidt,
Kelly E Manning,
Stephanie L Foster,
Robert L Atmar,
Kirsten E. Lyke,
Martin R. Gaudinski,
Walker P Black,
Julie E. Ledgerwood,
John N Misasi,
Paul C. Roberts,
John R. Mascola,
Mehul S. Suthar,
David C. Montefiori
Posted 15 Dec 2021
medRxiv DOI: 10.1101/2021.12.15.21267805
Posted 15 Dec 2021
The Omicron variant of SARS-CoV-2 is raising concerns because of its increased transmissibility and potential for reduced susceptibility to antibody neutralization. To assess the potential risk of this variant to existing vaccines, serum samples from mRNA-1273 vaccine recipients were tested for neutralizing activity against Omicron and compared to neutralization titers against D614G and Beta in live virus and pseudovirus assays. Omicron was 41-84-fold less sensitive to neutralization than D614G and 5.3-7.4-fold less sensitive than Beta when assayed with serum samples obtained 4 weeks after 2 standard inoculations with 100 g mRNA-1273. A 50 g boost increased Omicron neutralization titers and may substantially reduce the risk of symptomatic vaccine breakthrough infections.
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