Booster of mRNA-1273 Strengthens SARS-CoV-2 Omicron Neutralization
By
Nicole Doria-Rose,
Xiaoying Shen,
Stephen D. Schmidt,
Sijy O'Dell,
Charlene McDanal,
Wenhong Feng,
Jin Tong,
Amanda Eaton,
Maha Maglinao,
Haili Tang,
Kelly E Manning,
Venkata-Viswanadh Edara,
Linlin Lai,
Madison Ellis,
Kathryn Moore,
Katharine Floyd,
Stephanie L Foster,
Robert L Atmar,
Kirsten E. Lyke,
Tongqing Zhou,
Lingshu Wang,
yi Zhang,
Martin R. Gaudinski,
Walker P Black,
Ingelise Gordon,
Mercy Guech,
Julie E. Ledgerwood,
John N Misasi,
Alicia Widge,
Paul C. Roberts,
John Beigel,
Bette Korber,
Rolando Pajon,
John R. Mascola,
Mehul S. Suthar,
David C. Montefiori
Posted 15 Dec 2021
medRxiv DOI: 10.1101/2021.12.15.21267805
The Omicron variant of SARS-CoV-2 is raising concerns because of its increased transmissibility and potential for reduced susceptibility to antibody neutralization. To assess the potential risk of this variant to existing vaccines, serum samples from mRNA-1273 vaccine recipients were tested for neutralizing activity against Omicron and compared to neutralization titers against D614G and Beta in live virus and pseudovirus assays. Omicron was 41-84-fold less sensitive to neutralization than D614G and 5.3-7.4-fold less sensitive than Beta when assayed with serum samples obtained 4 weeks after 2 standard inoculations with 100 g mRNA-1273. A 50 g boost increased Omicron neutralization titers and may substantially reduce the risk of symptomatic vaccine breakthrough infections.
Download data
- Downloaded 28,622 times
- Download rankings, all-time:
- Site-wide: 348
- In infectious diseases: 133
- Year to date:
- Site-wide: 153
- Since beginning of last month:
- Site-wide: 395
Altmetric data
Downloads over time
Distribution of downloads per paper, site-wide
PanLingua
News
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!