New antibiotics are needed against multidrug resistant Gram-negative pathogens that have compromised global health systems. Antimicrobial peptides are generally considered promising lead candidates for the next generation of antibiotics but have not fulfilled this expectation. Here we demonstrate activity of a cationic amphipathic undecapeptide (ChIP; Charge change Independent Peptide) against a wide panel of multidrug resistant Gram-negative pathogens. Importantly, the antimicrobial activity of ChIP is independent of the surface charge changes that confer colistin resistance through modification of Lipid A, while decreased activity of ChIP correlates with GlcN1 tri-acylation of Lipid A. In an in vivo peritonitis mouse model ChIP displays excellent activity against both colistin sensitive and resistant Escherichia coli and Acinetobacter baumannii strains.

Download data

• Downloaded 203 times
• Download rankings, all-time:
  • Site-wide: 160,741
  • In microbiology: 11,874
• Year to date:
  • Site-wide: 22,364
• Since beginning of last month:
  • Site-wide: 70,012

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide