Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 62,232 bioRxiv papers from 276,305 authors.

Mendelian randomization does not support serum calcium in prostate cancer risk

By James Yarmolinsky, Katie Berryman, Ryan Langdon, Carolina Bonilla, the PRACTICAL consortium, George Davey Smith, Richard M Martin, Sarah J Lewis

Posted 09 Apr 2018
bioRxiv DOI: 10.1101/297721 (published DOI: 10.1007/s10552-018-1081-5)

Background: Observational studies suggest that dietary and serum calcium are risk factors for prostate cancer. However, such studies suffer from residual confounding (due to unmeasured or imprecisely measured confounders), undermining causal inference. Mendelian randomization uses randomly assigned (hence unconfounded and pre-disease onset) germline genetic variation to proxy for phenotypes and strengthen causal inference in observational studies. Objective: We tested the hypothesis that serum calcium is associated with an increased risk of overall and advanced prostate cancer. Design: A genetic instrument was constructed using 5 single nucleotide polymorphisms robustly associated with serum calcium in a genome-wide association study (N ≤ 61,079). This instrument was then used to test the effect of a 0.5 mg/dL increase (1 standard deviation, SD) in serum calcium on risk of prostate cancer in 72,729 men in the PRACTICAL (Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome) Consortium (44,825 cases, 27,904 controls) and risk of advanced prostate cancer in 33,498 men (6,263 cases, 27,235 controls). Results: We found weak evidence for a protective effect of serum calcium on prostate cancer risk (odds ratio [OR] per 0.5 mg/dL increase in calcium: 0.83, 95% CI: 0.63-1.08; P=0.12). We did not find strong evidence for an effect of serum calcium on advanced prostate cancer (OR per 0.5 mg/dL increase in calcium: 0.98, 95% CI: 0.57-1.70; P=0.93). Conclusions: Our Mendelian randomization analysis does not support the hypothesis that serum calcium increases risk of overall or advanced prostate cancer.

Download data

  • Downloaded 185 times
  • Download rankings, all-time:
    • Site-wide: 45,203 out of 62,232
    • In epidemiology: 878 out of 1,556
  • Year to date:
    • Site-wide: 53,382 out of 62,232
  • Since beginning of last month:
    • Site-wide: 40,158 out of 62,232

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide

Sign up for the Rxivist weekly newsletter! (Click here for more details.)