Rxivist logo

Gut-testis axis: microbiota-(n-3) PUFA improving semen quality in type 1 diabetes

By Yong Zhao, Yanan Hao, Yanni Feng, Xiaowei Yan, Liang Chen, Ruqing Zhong, Xiangfang Tang, Wei Shen, Qing-Yuan Sun, Zhongyi Sun, Yonglin Ren, Hongfu Zhang

Posted 25 Nov 2021
bioRxiv DOI: 10.1101/2021.11.24.469971

Gut dysbiosis and type 1 diabetes (T1D) are closely related, and gut dysbiosis and male infertility are correlated, too. Moreover, most male T1D patients are of active reproductive age. Therefore, it is crucial to explore possible means for improving their semen quality. Here, we found that fecal microbiota transplantation (FMT) from alginate oligosaccharide (AOS) improved gut microbiota (A10-FMT) significantly decreased blood glucose and glycogen, and increased semen quality in streptozotocin-induced T1D subjects. A10-FMT improved T1D-disturbed gut microbiota, especially the increase in small intestinal lactobacillus, and blood and testicular metabolome to produce n-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) to ameliorate spermatogenesis and semen quality. Moreover, A10-FMT can improve spleen and liver function to strengthen the systemic environment for sperm development. FMT from gut microbiota of control animals (Con-FMT) produced some beneficial effects; however, to a smaller extent. Thus, AOS improved gut microbiota may be a useful protocol for improving semen quality and male fertility in T1D patients.

Download data

  • Downloaded 212 times
  • Download rankings, all-time:
    • Site-wide: 168,131
    • In developmental biology: 4,466
  • Year to date:
    • Site-wide: 46,735
  • Since beginning of last month:
    • Site-wide: 46,286

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide