Validating silicon polytrodes with paired juxtacellular recordings: method and dataset
Joana Pereira Neto,
Adam Raymond Kampff
Posted 26 Jan 2016
bioRxiv DOI: 10.1101/037937 (published DOI: 10.1152/jn.00103.2016)
Posted 26 Jan 2016
Cross-validating new methods for recording neural activity is necessary to accurately interpret and compare the signals they measure. Here we describe a procedure for precisely aligning two probes for in vivo paired-recordings such that the spiking activity of a single neuron is monitored with both a dense extracellular silicon polytrode and a juxtacellular micro-pipette. Our new method allows for efficient, reliable, and automated guidance of both probes to the same neural structure with micron resolution. We also describe a new dataset of paired-recordings, which is available online. We propose that our novel targeting system, and ever expanding cross-validation dataset, will be vital to the development of new algorithms for automatically detecting/sorting single-units, characterizing new electrode materials/designs, and resolving nagging questions regarding the origin and nature of extracellular neural signals.
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