Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 57,822 bioRxiv papers from 266,142 authors.
Cytokine and Leukocyte Profiling Reveal Pro-Inflammatory and Autoimmune Features in Frontotemporal Dementia Patients
Philipp A. Jaeger,
Trisha M. Stan,
Bradley F. Boeve,
Adam L. Boxer,
Gabriela K. Fragiadakis,
Neill R. Graff-Radford,
David S. Knopman,
Holde T. Maecker,
Bruce L Miller,
Posted 22 Apr 2016
bioRxiv DOI: 10.1101/049791
Posted 22 Apr 2016
The growing link between systemic environment and brain function opens the possibility that cellular communication and composition in blood are correlated with brain health. We tested this concept in frontotemporal dementia with novel, unbiased tools that measure hundreds of soluble signaling proteins or characterize the vast immune cell repertoire in blood. With these tools we discovered complementary abnormalities indicative of abnormal T cell populations and autoimmunity in frontotemporal dementia.
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