Rxivist logo

MPDB: a unified multi-domain protein structure database integrating structural analogue detection

By Chunxiang Peng, Xiaogen Zhou, Yuhao Xia, Yang Zhang, Guijun Zhang

Posted 28 Oct 2021
bioRxiv DOI: 10.1101/2021.10.27.466092

With the development of protein structure prediction methods and biological experimental determination techniques, the structure of single-domain proteins can be relatively easier to be modeled or experimentally solved. However, more than 80% of eukaryotic proteins and 67% of prokaryotic proteins contain multiple domains. Constructing a unified multi-domain protein structure database will promote the research of multi-domain proteins, especially in the modeling of multi-domain protein structures. In this work, we develop a unified multi-domain protein structure database (MPDB). Based on MPDB, we also develop a server with two functional modules: (1) the culling module, which filters the whole MPDB according to input criteria; (2) the detection module, which identifies structural analogues of the full-chain according to the structural similarity between input domain models and the protein in MPDB. The module can discover the potential analogue structures, which will contribute to high-quality multi-domain protein structure modeling.

Download data

  • Downloaded 123 times
  • Download rankings, all-time:
    • Site-wide: 197,468
    • In bioinformatics: 14,025
  • Year to date:
    • Site-wide: 132,639
  • Since beginning of last month:
    • Site-wide: 169,443

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

News