Gut microbiota analyses of Saudi populations for type 2 diabetes-related phenotypes reveals significant association
Fahad A Al-Muhanna,
Alexa k Dodwell,
Abdulmohsen H Al Eleq,
Abdullah M Al-Rubaish,
Waleed I Albaker,
Ali I Al-Sultan,
Khalid R Alkharsah,
Raed M Sulaiman,
Abdulaziz A Al-Qurain,
Cyril Kadhem Cyrus,
Rudaynah A AlAli,
Fred L Robinson,
Andrew W Brooks,
Afnan F Almuhanna,
Brendan J Keating,
Brian D Piening
Posted 25 Oct 2021
bioRxiv DOI: 10.1101/2021.10.25.465666
Posted 25 Oct 2021
Large-scale gut microbiome sequencing has revealed key links between microbiome dysfunction and metabolic diseases such as T2D. To date, these efforts have largely focused on Western populations, with few studies assessing T2D microbiota associations in Middle Eastern communities where T2D prevalence is now over 20%. We analyzed the composition of stool 16S rRNA from 461 T2D and 119 non-T2Dparticipants from the Eastern Province of Saudi Arabia. We quantified the abundance of microbial communities to examine any significant differences between subpopulations of samples based on diabetes status and glucose level. We observed overall positive enrichment within diabetics compared to healthy individuals and amongst diabetic participants; those with high glucose levels exhibited slightly more positive enrichment compared to those at lower risk of fasting hyperglycemia. In particular, the genus Firmicutes was upregulated in diabetic participants compared to non-diabetic participants, and T2D was associated with an elevated Firmicutes/Bacteroidetes ratio, consistent with previous findings. Based on diabetes status and glucose levels of Saudi participants, relatively stable differences in stool composition were perceived by differential abundance and alpha diversity measures.
- Downloaded 64 times
- Download rankings, all-time:
- Site-wide: 170,241
- In microbiology: 13,071
- Year to date:
- Site-wide: 39,829
- Since beginning of last month:
- Site-wide: 30,840
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!