Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 52,519 bioRxiv papers from 243,473 authors.

Potent optogenetic inhibition of behavior with anion channelrhodopsins

By Farhan Mohammad, James Stewart, Stanislav Ott, Katarina Chlebikova, Jia Yi Chua, Tong-Wey Koh, Joses Ho, Adam Claridge-Chang

Posted 20 Oct 2016
bioRxiv DOI: 10.1101/082255 (published DOI: 10.1038/nmeth.4148)

Optogenetics employs light exposure to manipulate physiology in genetically modified organisms. There are abundant tools for optogenetic excitation of neuronal activity, but the limitations of current activity photo-inhibitors present an obstacle to demonstrating the necessity of specific neuronal circuits. Here we show that anion channelrhodopsins can be used to specifically and rapidly inhibit a range of systems involved in Drosophila locomotion, wing expansion, memory retrieval and gustation, demonstrating their broad utility to the circuit analysis of behavior.

Download data

  • Downloaded 2,361 times
  • Download rankings, all-time:
    • Site-wide: 1,385 out of 52,519
    • In neuroscience: 193 out of 9,207
  • Year to date:
    • Site-wide: 10,092 out of 52,519
  • Since beginning of last month:
    • Site-wide: 7,748 out of 52,519

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News