Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 52,519 bioRxiv papers from 243,473 authors.
Potent optogenetic inhibition of behavior with anion channelrhodopsins
Jia Yi Chua,
Posted 20 Oct 2016
bioRxiv DOI: 10.1101/082255 (published DOI: 10.1038/nmeth.4148)
Posted 20 Oct 2016
Optogenetics employs light exposure to manipulate physiology in genetically modified organisms. There are abundant tools for optogenetic excitation of neuronal activity, but the limitations of current activity photo-inhibitors present an obstacle to demonstrating the necessity of specific neuronal circuits. Here we show that anion channelrhodopsins can be used to specifically and rapidly inhibit a range of systems involved in Drosophila locomotion, wing expansion, memory retrieval and gustation, demonstrating their broad utility to the circuit analysis of behavior.
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