Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 57,294 bioRxiv papers from 263,837 authors.

Bridging multiple scales in the human brain using computational modelling

By Michael Schirner, Anthony Randal McIntosh, Viktor Jirsa, Gustavo Deco, Petra Ritter

Posted 03 Nov 2016
bioRxiv DOI: 10.1101/085548 (published DOI: 10.7554/eLife.28927)

Brain dynamics span multiple spatial and temporal scales, from fast spiking neurons to slow fluctuations over distributed areas. No single experimental method links data across scales. Here, we bridge this gap using The Virtual Brain connectome-based modelling platform to integrate multimodal data with biophysical models and support neurophysiological inference. Simulated cell populations were linked with subject-specific white-matter connectivity estimates and driven by electroencephalography-derived electric source activity. The models were fit to subject-specific resting-state functional magnetic resonance imaging data, and overfitting was excluded using 5-fold cross-validation. Further evaluation of the models show how balancing excitation with feedback inhibition generates an inverse relationship between α-rhythms and population firing on a faster time scale and resting-state network oscillations on a slower time scale. Lastly, large-scale interactions in the model lead to the emergence of scale-free power-law spectra. Our novel findings underscore the integrative role for computational modelling to complement empirical studies.

Download data

  • Downloaded 738 times
  • Download rankings, all-time:
    • Site-wide: 10,262 out of 57,294
    • In neuroscience: 1,618 out of 10,055
  • Year to date:
    • Site-wide: 41,539 out of 57,294
  • Since beginning of last month:
    • Site-wide: 48,139 out of 57,294

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News