Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 67,027 bioRxiv papers from 295,009 authors.

Functional Connectivity Dynamics of the Resting State across the Human Adult Lifespan

By Demian Battaglia, Thomas Boudou, Enrique C. A. Hansen, Sabrina Chettouf, Andreas Daffertshofer, A Randel McIntosh, Joelle Zimmermann, Petra Ritter, Viktor Jirsa

Posted 09 Feb 2017
bioRxiv DOI: 10.1101/107243

The aging brain undergoes alterations of both Structural Connectivity (SC) and time- averaged Functional Connectivity in the resting state (rs FC). Here, we show by means of functional MRI (fMRI) human brain imaging that aging also profoundly impacts on the spontaneous temporal reconfiguration of this rs FC. Analyzing time-dependent correlations between human rs fMRI blood oxygen level dependent (BOLD) time series, we describe Functional Connectivity Dynamics (FCD) as a switching between epochs of meta-stable FC and transients of fast network reconfiguration. We find that the flux of FCD markedly slows down and becomes more "viscous" across the adult lifespan (18-80 yrs), also accounting for the wide inter-subject variability of performance observed in cognitive screening tasks. Such remodeling of FCD discloses qualitatively novel effects of aging that cannot be captured by variations of SC or of static FC, opening the way to improved imaging-based characterizations of the functional mechanisms underlying cognitive aging.

Download data

  • Downloaded 1,786 times
  • Download rankings, all-time:
    • Site-wide: 2,926 out of 67,027
    • In neuroscience: 448 out of 12,010
  • Year to date:
    • Site-wide: 10,722 out of 67,027
  • Since beginning of last month:
    • Site-wide: 25,126 out of 67,027

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News