Rxivist logo

Short Term Reduction in the Odds of Testing Positive for SARS-CoV-2; a Comparison Between Two Doses and Three doses of the BNT162b2 Vaccine

By Tal Patalon, Sivan Gazit, Virginia E. Pitzer, Ottavia Prunas, Joshua L Warren, Daniel M Weinberger

Posted 31 Aug 2021
medRxiv DOI: 10.1101/2021.08.29.21262792

With the evidence of waning immunity of the BNT162b2 vaccine, a national third dose vaccination campaign was initiated in Israel during August 2021; other countries have announced their intention to administer a booster shot as well. Leveraging data from Maccabi Healthcare Services, we conducted a preliminary retrospective study aimed at evaluating initial short-term effectiveness of a three dose versus a two dose regimen against infection due to the Delta variant of SARS-CoV-2, using two complementary approaches; a test-negative design and a matched case-control design. We found that 7-13 days after the booster shot there is a 48-68% reduction in the odds of testing positive for SARS-CoV-2 infection and that 14-20 days after the booster the marginal effectiveness increases to 70-84%. Further studies are needed to determine the duration of protection conferred by the third dose and its effect on severe disease.

Download data

  • Downloaded 24,063 times
  • Download rankings, all-time:
    • Site-wide: 463
    • In infectious diseases: 177
  • Year to date:
    • Site-wide: 11,355
  • Since beginning of last month:
    • Site-wide: 6,238

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

News