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Integrative Structural Brain Network Analysis In Diffusion Tensor Imaging

By Moo K. Chung, Jamie L. Hanson, Nagesh Adluru, Andrew L. Alexander, Richard J. Davidson, Seth D. Pollak

Posted 20 Apr 2017
bioRxiv DOI: 10.1101/129015 (published DOI: 10.1089/brain.2016.0481)

In diffusion tensor imaging, structural connectivity between brain regions is often measured by the number of white matter fiber tracts connecting them. Other features such as the length of tracts or fractional anisotropy (FA) are also used in measuring the strength of connectivity. In this study, we investigated the effects of incorporating the number of tracts, the tract length and FA-values into the connectivity model. Using various node-degree based graph theory features, the three connectivity models are compared. The methods are applied in characterizing structural networks between normal controls and maltreated children, who experienced maltreatment while living in post-institutional settings before being adopted by families in the US.

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