Rxivist logo

DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation and preimplantation development

By Zhiyuan Chen, Zhenfei Xie, Yi Zhang

Posted 19 Aug 2021
bioRxiv DOI: 10.1101/2021.08.19.457017

How maternal factors in oocytes initiate zygotic genome activation (ZGA) remains elusive. Recent studies indicate that DPPA2 and DPPA4 are required for establishing a 2-cell embryo-like (2C-like) state in mouse embryonic stem cells (ESCs) in a DUX-dependent manner. These results suggest that DPPA2 and DPPA4 are essential maternal factors that regulate Dux and ZGA in embryos. By analyzing maternal knockout and maternal-zygotic knockout embryos, we unexpectedly found that Dux activation, ZGA, and preimplantation development are normal in embryos without DPPA2 or DPPA4. Thus, unlike in ESCs/2C-like cells, DPPA2 and DPPA4 are dispensable for ZGA and preimplantation development.

Download data

  • Downloaded 332 times
  • Download rankings, all-time:
    • Site-wide: 99,626
    • In developmental biology: 2,706
  • Year to date:
    • Site-wide: 23,128
  • Since beginning of last month:
    • Site-wide: 11,536

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

News