Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 66,889 bioRxiv papers from 294,492 authors.

Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure

By Fernando J Sánchez-Valdéz, Angel Padilla, Wei Wang, Dylan Orr, Rick L. Tarleton

Posted 19 Dec 2017
bioRxiv DOI: 10.1101/235762 (published DOI: 10.7554/elife.34039)

The ability of the Chagas disease agent Trypanosoma cruzi to resist extended in vivo exposure to highly effective trypanocidal compounds prompted us to explore the potential for dormancy and its contribution to failed drug treatments in this infection. We document the development of non-proliferating intracellular amastigotes in vivo and in vitro in the absence of drug treatment. Non-proliferative amastigotes ultimately converted to trypomastigotes and established infections in new host cells. Most significantly, dormant amastigotes were uniquely resistant to extended drug treatment in vivo and in vitro and could re-establish a flourishing infection after as many as 30 days of drug exposure. These results demonstrate a dormancy pathway in T. cruzi that accounts for the failure of highly cytotoxic compounds to completely resolve the infection. The ability of T. cruzi to establish dormancy throws into question current methods for identifying curative drugs but also suggests alternative therapeutic approaches.

Download data

  • Downloaded 346 times
  • Download rankings, all-time:
    • Site-wide: 31,488 out of 66,889
    • In microbiology: 1,951 out of 5,381
  • Year to date:
    • Site-wide: 42,958 out of 66,889
  • Since beginning of last month:
    • Site-wide: 45,444 out of 66,889

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News