Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 72,966 bioRxiv papers from 317,712 authors.

Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

By Xueyi Shen, Lianne M Reus, Simon R. Cox, Mark J. Adams, David C Liewald, Mark E. Bastin, Daniel J. Smith, Ian J. Deary, Heather C Whalley, Andrew M. McIntosh

Posted 22 Aug 2016
bioRxiv DOI: 10.1101/070912 (published DOI: 10.1038/s41598-017-05507-6)

Previous reports of altered grey and white matter structure in Major Depressive Disorder (MDD) have been inconsistent. Recent meta-analyses have, however, reported reduced hippocampal grey matter volume in MDD and reduced white matter integrity in several brain regions. The use of different diagnostic criteria, scanners and imaging sequences may, however, obscure further anatomical differences. In this study, we tested for differences in subcortical grey matter volume (n=1157) and white matter integrity (n=1089) between depressed individuals and controls in the subset of 8590 UK Biobank Imaging study participants who had undergone depression assessments. Whilst we found no significant differences in subcortical volumes, significant reductions were found in depressed individuals versus controls in global white matter integrity, as measured by fractional anisotropy (FA) (β=-0.182, p=0.005). We also found reductions in FA in association/commissural fibres (β=-0.184, pcorrected=0.010) and thalamic radiations (β=-0.159, pcorrected=0.020). Tract-specific FA reductions were also found in the left superior longitudinal fasciculus (β=-0.194, pcorrected=0.025), superior thalamic radiation (β=-0.224, pcorrected=0.009) and forceps major (β=-0.193, pcorrected=0.025) in depression (all betas standardised). Our findings provide further evidence for disrupted white matter integrity in MDD.

Download data

  • Downloaded 963 times
  • Download rankings, all-time:
    • Site-wide: 9,163 out of 72,951
    • In neuroscience: 1,455 out of 13,110
  • Year to date:
    • Site-wide: 54,753 out of 72,951
  • Since beginning of last month:
    • Site-wide: 54,753 out of 72,951

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News