Rxivist logo

Loss of CaMKI function disrupts salt aversive learning in C. elegans

By Jana P. Lim, Holger Fehlauer, Dominique A. Glauser, Anne Brunet, Miriam B. Goodman

Posted 14 Jun 2017
bioRxiv DOI: 10.1101/149682 (published DOI: 10.1523/JNEUROSCI.1611-17.2018)

The ability to adapt behavior to environmental fluctuations is critical for survival of organisms ranging from invertebrates to mammals. Caenorhabditis elegans can learn to avoid sodium chloride when it is paired with starvation. This behavior is likely advantageous to avoid areas without food. While some genes have been implicated in this salt aversive learning behavior, critical genetic components, and the neural circuit in which they act, remain elusive. Here, we show that the sole worm ortholog of mammalian CaMKI/IV, CMK-1, is essential for salt aversive learning behavior in C. elegans. We find that CMK-1 acts in the primary salt-sensing ASE neurons to regulate this behavior. By characterizing the intracellular calcium dynamics in ASE neurons using microfluidics, we find that loss of cmk-1 leads to an altered pattern of sensory-evoked calcium responses that may underlie salt aversive learning. Our study implicates the conserved CaMKI/CMK-1 as an essential cell-autonomous regulator for behavioral plasticity to environmental salt in C. elegans.

Download data

  • Downloaded 373 times
  • Download rankings, all-time:
    • Site-wide: 41,009 out of 84,782
    • In neuroscience: 7,130 out of 15,097
  • Year to date:
    • Site-wide: 69,759 out of 84,782
  • Since beginning of last month:
    • Site-wide: 77,186 out of 84,782

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)