Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 57,506 bioRxiv papers from 264,779 authors.

Isolated from input: Evidence of default mode network support for perceptually-decoupled and conceptually-guided cognition

By Charlotte Murphy, Elizabeth Jefferies, Shirley-Ann Rueschemeyer, Mladen Sormaz, Hao-ting Wang, Daniel S. Margulies, Jonathan Smallwood

Posted 15 Jun 2017
bioRxiv DOI: 10.1101/150466 (published DOI: 10.1016/j.neuroimage.2018.01.017)

The default mode network supports a variety of mental operations such as semantic processing, episodic memory retrieval, mental time travel and mind-wandering, yet the commonalities between these functions remains unclear. One possibility is that this system supports cognition that is independent of the immediate environment; alternatively or additionally, it might support higher-order conceptual representations that draw together multiple features. We tested these accounts using a novel paradigm that separately manipulated the availability of perceptual information to guide decision-making and the representational complexity of this information. Using task based imaging we established regions that respond when cognition combines both stimulus independence with multi-modal information. These included left and right angular gyri and the left middle temporal gyrus. Although these sites were within the default mode network, they showed a stronger response to demanding memory judgements than to an easier perceptual task, contrary to the view that they support automatic aspects of cognition. In a subsequent analysis, we showed that these regions were located at the extreme end of a macroscale gradient, which describes gradual transitions from sensorimotor to transmodal cortex. This shift in the focus of neural activity towards transmodal, default mode, regions might reflect a process of isolation from specific sensory inputs that enables conceptually rich cognitive states to be generated in the absence of input.

Download data

  • Downloaded 541 times
  • Download rankings, all-time:
    • Site-wide: 15,881 out of 57,506
    • In neuroscience: 2,596 out of 10,103
  • Year to date:
    • Site-wide: 36,408 out of 57,506
  • Since beginning of last month:
    • Site-wide: 30,265 out of 57,506

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News