Severity, criticality, and fatality of the SARS-CoV-2 Beta variant
Laith J Abu-Raddad,
Houssein H. Ayoub,
HADI M. YASSINE,
Hebah A. Al Khatib,
Patrick J Tang,
Mohammad Rubayet Hasan,
Einas Al Kuwari,
Anvar Hassan Kaleeckal,
Ali Nizar Latif,
Riyazuddin Mohammad Shaik,
Hanan F. Abdul Rahim,
Mohamed Ghaith Al Kuwari,
Adeel A Butt,
Hamad Eid Al Romaihi,
Mohamed H. Al-Thani,
Abdullatif Al Khal,
Posted 04 Aug 2021
medRxiv DOI: 10.1101/2021.08.02.21261465
Posted 04 Aug 2021
Severity (acute-care hospitalization), criticality (ICU hospitalization), and fatality of SARS-CoV-2 Beta (B.1.351) variant was investigated through case-control studies applied to complete national cohorts of infection, disease, and death cases in Qatar. Compared to Alpha (B.1.1.7) variant, odds of progressing to severe disease were 1.24-fold (95% CI: 1.11-1.39) higher for Beta. Odds of progressing to critical disease were 1.49-fold (95% CI: 1.13-1.97) higher. Odds of COVID-19 death were 1.57-fold (95% CI: 1.03-2.43) higher. Findings highlight risks to healthcare systems, particularly to intensive care facilities and resources, with increased circulation of Beta.
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