Rxivist logo

New susceptibility loci for severe COVID-19 by detailed GWAS analysis in European populations

By Frauke Degenhardt, David Ellinghaus, Simonas Juzenas, Jon Lerga-Jaso, Mareike Wendorff, Douglas Maya-Miles, Florian Uellendahl-Werth, Hesham ElAbd, Malte Christoph Ruehlemann, Jatin Arora, Onur oezer, Ole Bernt Lenning, Ronny Myhre, May Sissel Vadla, Eike Matthias Wacker, Lars Wienbrandt, Aaron Blandino Ortiz, Adolfo de Salazar, Adolfo Garrido Chercoles, Adriana Palom, Agustin Ruiz, Alberto Mantovani, Alberto Zanella, Aleksander Rygh Holten, Alena Mayer, Alessandra Bandera, Alessandro Cherubini, Alessandro Protti, Alessio Aghemo, Alessio Gerussi, Alexander Popov, Alfredo Ramirez, Alice Braun, Almut Nebel, Ana Barreira, Ana Lleo, Ana Teles, Anders Benjamin Kildal, Andrea Biondi, Andrea Ganna, Andrea Gori, Andreas Glueck, Andreas Lind, Anke Hinney, Anna Carreras Nolla, Anna Ludovica Fracanzani, Annalisa Cavallero, Anne Ma Dyrhol-Riise, Antonella Ruello, Antonio Julia, Antonio Muscatello, Antonio Pesenti, Antonio Voza, Ariadna Rando-Segura, Aurora Solier, Beatriz Cortes, Beatriz Mateos, Beatriz Nafria-Jimenez, Benedikt Schaefer, Bjoern Jensen, Carla Bellinghausen, Carlo Maj, Carlos Ferrando, Carmen de la Horrra, Carmen Quereda, Carsten Skurk, Charlotte Thibeault, Chiara Scollo, Christian Herr, Christoph D. Spinner, Christoph Lange, Cinzia Hu, Clara Lehmann, Claudio Cappadona, Clinton Azuure, COVICAT study group, Covid-19 Aachen Study (COVAS), Cristiana Bianco, Cristina Sancho, Dag Arne Lihaug Hoff, Daniela Galimberti, Daniele Prati, David Haschka, David Jimenez, David Pestana, David Toapanta, Elena Azzolini, Elio Scarpini, Elisa T. Helbig, Eloisa Urrechaga, Elvezia Maria Paraboschi, Emanuele Pontali, Enric Reverter, Enrique J. Calderon, Enrique Navas, Erik Solligard, Ernesto Contro, Eunate Arana, Federico Garcia, Felix Garcia Sanchez, Ferruccio Ceriotti, Filippo Martinelli-Boneschi, Flora Peyvandi, Florian Kurth, Francesco Blasi, Francesco Malvestiti, Francisco J. Medrano, Francisco Mesonero, Francisco Rodriguez-Frias, Frank Hanses, Fredrik Mueller, Giacomo Bellani, Giacomo Grasselli, Gianni Pezzoli, Giorgio Costantino, Giovanni Albano, Giuseppe Bellelli, Giuseppe Citerio, Giuseppe Foti, Giuseppe Lamorte, Holger Neb, Ilaria My, Ingo Kurth, Isabel Hernandez, Isabell Pink, Itziar de Rojas, Ivan Galvan-Femenia, Jan C. Holter, Jan Egil Egil Afset, Jan Heyckendorf, Jan Damas, Jan Kristian Rybniker, Janine Altmueller, Javier Ampuero, Jesus M Banales, Joan Ramon Badia, Joaquin Dopazo, Jochen Schneider, Jonas Bergan, Jordi Barretina, Joern Walter, Jose Hernandez Quero, Josune Goikoetxea, Juan Delgado, Juan M. Guerrero, Julia Fazaal, Julia Kraft, Julia Schroeder, Kari Risnes, Karina Banasik, Karl Erik Mueller, Karoline I. Gaede, Koldo Garcia-Etxebarria, Kristian Tonby, Lars Heggelund, Laura Izquierdo-Sanchez, Laura Rachele Bettini, Lauro Sumoy, Leif Erik Sander, Lena J. Lippert, Leonardo Terranova, Lindokuhle Nkambule, Lisa Knopp, Lise Tuset Gustad, Lucia Garbarino, Luigi Santoro, Luis Tellez, Luisa Roade, Mahnoosh Ostadreza, Maider Intxausti, Manolis Kogevinas, Mar Riveiro-Barciela, Marc M. Berger, Mari E.K. Niemi, Maria A. Gutierrez-Stampa, Maria Grazia Valsecchi, Maria Hernandez-Tejero, Maria J.G.T. Vehreschild, Maria Manunta, Mariella D'Angio, Marina Cazzaniga, Marit M. Grimsrud, Markus Cornberg, Markus M. Noethen, Marta Marquie, Massimo Castoldi, Mattia Cordioli, Maurizio Cecconi, Mauro D'Amato, Max Augustin, Melissa Tomasi, Merce Boada, Michael Dreher, Michael J. Seilmaier, Michael Joannidis, Michael Wittig, Michela Mazzocco, Miguel Rodriguez-Gandia, Natale Imaz Ayo, Natalia Blay, Natalia Chueca, Nicola Montano, Nicole Ludwig, Nikolaus Marx, Nilda Martinez, Norwegian SARS-CoV-2 Study group, Oliver A. Cornely, Oliver Witzke, Orazio Palmieri, Pa COVID-19 Study Group, Paola Faverio, Paolo Bonfanti, Paolo Tentorio, Pedro Castro, Pedro M. Rodrigues, Pedro Pablo Espana, Per Hoffmann, Philip Rosenstiel, Philipp Schommers, Phillip Suwalski, Raul de Pablo, Ricard Ferrer, Robert Bals, Roberta Gualtierotti, Rocio Gallego-Duran, Rosa Nieto, Rossana Carpani, Ruben Morilla, Salvatore Badalamenti, Sammra Haider, Sandra Ciesek, Sandra May, Sara Bombace, Sara Marsal, Sara Pigazzini, Sebastian Klein, Selina Rolker, Serena Pelusi, Sibylle Wilfling, Silvano Bosari, Soren Brunak, Soumya Raychaudhuri, Stefan Schreiber, Stefanie Heilmann-Heimbach, Stefano Aliberti, Stephan Ripke, Susanne Dudman, The Humanitas COVID-19 Task Forse, The Humanitas Gavazzeni COVID-19 Task Force, Thomas Bahmer, Thomas Eggermann, Thomas Illig, Thorsten Brenner, Torsten Feldt, Trine Folseraas, Trinidad Gonzalez Cejudo, Ulf Landmesser, Ulrike Protzer, Ute Hehr, Valeria Rimoldi, Vegard Skogen, Verena Keitel, Verena Kopfnagel, Vicente Friaza, Victor Andrade, Victor Moreno, Wolfgang Poller, Xavier Farre, Xiaomin Wang, Yascha Khodamoradi, Zehra Karadeniz, Anna Latiano, Siegfried Goerg, Petra Bacher, Philipp Koehler, Florian Tran, Heinz Zoller, Eva C Schulte, Bettina Heidecker, Kerstin U Ludwig, Javier Fernandez, Manuel Romero-Gomez, Agustin Albillos, Pietro Invernizzi, Maria Buti, Stefano Duga, Luis Bujanda, Johannes R. Hov, Tobias L. Lenz, Rosanna Asselta, Rafael de Cid, Luca Valenti, Tom H. Karlsen, Mario Caceres, Andre Franke

Posted 23 Jul 2021
medRxiv DOI: 10.1101/2021.07.21.21260624

Due to the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), deepening the host genetic contribution to severe COVID-19 may further improve our understanding about underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of 3,260 COVID-19 patients with respiratory failure and 12,483 population controls from Italy, Spain, Norway and Germany, as well as hypothesis-driven targeted analysis of the human leukocyte antigen (HLA) region and chromosome Y haplotypes. We include detailed stratified analyses based on age, sex and disease severity. In addition to already established risk loci, our data identify and replicate two genome-wide significant loci at 17q21.31 and 19q13.33 associated with severe COVID-19 with respiratory failure. These associations implicate a highly pleiotropic ~0.9-Mb 17q21.31 inversion polymorphism, which affects lung function and immune and blood cell counts, and the NAPSA gene, involved in lung surfactant protein production, in COVID-19 pathogenesis.

Download data

  • Downloaded 1,074 times
  • Download rankings, all-time:
    • Site-wide: 23,636
    • In genetic and genomic medicine: 103
  • Year to date:
    • Site-wide: 3,790
  • Since beginning of last month:
    • Site-wide: 2,100

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

News