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Rapid whole brain imaging of neural activity in freely behaving larval zebrafish (Danio rerio)

By Lin Cong, Zeguan Wang, Yuming Chai, Wei Hang, Chunfeng Shang, Wenbin Yang, Lu Bai, Jiulin Du, Kai Wang, Quan Wen

Posted 28 Apr 2017
bioRxiv DOI: 10.1101/131532 (published DOI: 10.7554/eLife.28158)

The internal brain dynamics that link sensation and action are arguably better studied during natural animal behaviors. Here we report on a novel volume imaging and 3D tracking technique that monitors whole brain neural activity in freely swimming larval zebrafish (Danio rerio). We demonstrated the capability of our system through functional imaging of neural activity during visually evoked and prey capture behaviors in larval zebrafish.

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