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Communication from learned to innate olfactory processing centers is required for memory retrieval in Drosophila

By Michael-John Dolan, Ghislain Belliart-Guérin, Alexander S. Bates, Yoshinori Aso, Shahar Frechter, Ruairí J.V. Roberts, Philipp Schlegel, Allan Wong, Adnan Hammad, Davi D. Bock, Gerald M. Rubin, Thomas Preat, Pierre-Yves Plaçais, Gregory S.X.E. Jefferis

Posted 25 Jul 2017
bioRxiv DOI: 10.1101/167312 (published DOI: 10.1016/j.neuron.2018.08.037)

Animals can show either learned or innate behavioral responses to a given stimulus. How these circuits interact to produce an appropriate behavioral response is unknown. In the Drosophila olfactory system, the lateral horn (LH) and the mushroom body (MB) are thought to mediate innate and learned olfactory behavior respectively, although the function of the LH has not been directly tested. Here we identify two LH cell-types (PD2a1/b1) that receive input from an MB output neuron required for recall of aversive olfactory memories. In contrast to the model above we find that PD2a1/b1 are required for aversive memory retrieval. PD2a1/b1 activity is modulated by training, indicating that memory information is passed to the innate olfactory processing centre. We map the connectivity of PD2a1/b1 to other olfactory neurons with connectomic data. This provides a circuit mechanism by which learned and unlearned olfactory information can interact to produce appropriate behavior.

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