Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 57,822 bioRxiv papers from 266,142 authors.

Intrinsic Hippocampal-Caudate Interaction Correlates with Human Navigation

By Xiang-Zhen Kong, Yi Pu, Xu Wang, Shan Xu, Xin Hao, Zonglei Zhen, Jia Liu

Posted 12 Mar 2017
bioRxiv DOI: 10.1101/116129

It has been indicated that both egocentric and allocentric representation systems exist in parallel, and combine to support spatial navigation according to the task. Identifying the neuronal mechanisms and functional roles of the interactions between the two systems promises to provide new insights into the organization of human navigation network. Here we combined resting-state fMRI and behavioral tasks to investigate how the core structures of these systems (i.e., hippocampus and caudate) functionally interact, and further examined their behavioral relevance in navigation in healthy young adults (N = 190). We found a slightly positive connectivity between the hippocampus and caudate (especially in good navigators), suggesting an effective hippocampal-caudate cross talk, which may facilitate the functional integration of the two systems. Interestingly, the hippocampal-caudate interaction correlated with better self-reported navigation ability. Moreover, using an extra 3D pointing task in virtual reality, we found that individual behavioral performance could be largely predicted by the hippocampal-caudate interactions. Overall, our study demonstrated the intrinsic interaction between two representation systems of the navigation network and its functional roles in behaviors, and further study on dynamic interaction would help us understand better their role in normal aging and psychiatric disorders.

Download data

  • Downloaded 280 times
  • Download rankings, all-time:
    • Site-wide: 31,870 out of 57,822
    • In neuroscience: 5,433 out of 10,200
  • Year to date:
    • Site-wide: 42,594 out of 57,822
  • Since beginning of last month:
    • Site-wide: 47,534 out of 57,822

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide

Sign up for the Rxivist weekly newsletter! (Click here for more details.)