Conserved Neural Circuit Structure Across Drosophila Larval Development Revealed By Comparative Connectomics
Throughout an animal's postembryonic development, neuronal circuits must maintain appropriate output even as the body grows. The contribution of structural adaptation --- neuronal morphology and synaptic connectivity --- to circuit development remains unclear. In a previous paper (Schneider-Mizell et al., 2016), we measured the detailed neuronal morphological structures subserving neuronal connectivity in Drosophila. Here, we examine how neuronal morphology and connectivity change across postembyronic development. Using new and existing serial section electron microscopy volumes, we reconstructed an identified nociceptive circuit in two larvae, one 1st instar and one 3rd instar. We found extremely consistent, topographically-arranged circuit structure. Five-fold increases in size of interneurons were associated with compensatory structural changes that maintained cell-type-specific synaptic input as a fraction of total inputs. An increase in number of synaptic contacts was accompanied with a disproportionate increase in the number of small dendritic terminal branches relative to other neuronal compartments. We propose that these precise patterns of structural growth act to conserve the computational function of a circuit, for example determining the location of a nociceptive stimulus.
- Downloaded 947 times
- Download rankings, all-time:
- Site-wide: 14,688 out of 101,349
- In neuroscience: 2,336 out of 18,061
- Year to date:
- Site-wide: 57,177 out of 101,349
- Since beginning of last month:
- Site-wide: 78,863 out of 101,349
Downloads over time
Distribution of downloads per paper, site-wide
- 20 Oct 2020: Support for sorting preprints using Twitter activity has been removed, at least temporarily, until a new source of social media activity data becomes available.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!