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A descending pathway facilitates undulatory wave propagation in Caenorhabditis elegans through gap junctions

By Tianqi Xu, Jing Huo, Shuai Shao, Michelle Po, Taizo Kawano, Yangning Lu, Min Wu, Mei Zhen, Quan Wen

Posted 17 Jun 2017
bioRxiv DOI: 10.1101/131490 (published DOI: 10.1073/pnas.1717022115)

Descending signals from the brain play critical roles in controlling and modulating locomotion kinematics. In the Caenorhabditis elegans nervous system, descending AVB premotor interneurons exclusively form gap junctions with B-type motor neurons that drive forward locomotion. We combined genetic analysis, optogenetic manipulation, and computational modeling to elucidate the function of AVB-B gap junctions during forward locomotion. First, we found that some B-type motor neurons generated intrinsic rhythmic activity, constituting distributed central pattern generators. Second, AVB premotor interneurons drove bifurcation of B-type motor neuron dynamics, triggering their transition from stationary to oscillatory activity. Third, proprioceptive couplings between neighboring B-type motor neurons entrained the frequency of body oscillators, forcing coherent propagation of bending waves. Despite substantial anatomical differences between the worm motor circuit and those in higher model organisms, we uncovered converging principles that govern coordinated locomotion.

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