Bovine tuberculosis, caused by both MTB(Mycobacterium tuberculosis) and MB(Mycobacterium bovis), is one of the most serious zoonotic diseases in the world. Both pathogenic MTB and MB interact closely with the host alveolar macrophages. However, the mechanisms of defense response of macrophages to MTB or MB still need further researches. Presently, in-depth comparative proteome analysis was performed on the MB- and MTB- infected macrophage. We identified that macrophages was more sensitive to the MB infection. Both pathogens could induce strong energy metabolism of macrophages. To eliminate MB and protect the host, a bunch of proteins and signaling which involved in autophagy- and inflammatory-related progresses were highly activated in macrophages following MB infection. In contrast, only proteins relevant to energy metabolisms were highly expressed in macrophages following MTB infection. In summary, we proposed that macrophages were more sensitive to MB attacks and could deployed proteins functioned in autophagy- and inflammatory-related progresses to protect the host. Our research provide a novel insight into the different mechanisms of defense responses of macrophages to both MTB and MB infection.
- Downloaded 55 times
- Download rankings, all-time:
- Site-wide: 157,557
- In bioinformatics: 11,819
- Year to date:
- Site-wide: 128,218
- Since beginning of last month:
- Site-wide: 104,460
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!