Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 57,524 bioRxiv papers from 264,866 authors.

Stereotypical Modulations In Dynamic Functional Connectivity Explained By Changes In BOLD Variance

By Katharina Glomb, Adrián Ponce-Alvarez, Matthieu Gilson, Petra Ritter, Gustavo Deco

Posted 12 Apr 2017
bioRxiv DOI: 10.1101/126524 (published DOI: 10.1016/j.neuroimage.2017.12.074)

Spontaneous activity measured in human subject under the absence of any task exhibits complex patterns of correlation that largely correspond to large-scale functional topographies obtained with a wide variety of cognitive and perceptual tasks. These “resting state networks” (RSNs) fluctuate over time, forming and dissolving on the scale of seconds to minutes. While these fluctuations, most prominently those of the default mode network, have been linked to cognitive function, it remains unclear whether they result from random noise or whether they index a non-stationary process which could be described as state switching. In this study, we use a sliding windows approach to relate temporal dynamics of RSNs to global modulations in correlation and BOLD variance. We compare empirical data, phase-randomized surrogate data, and data simulated with a stationary model. We find that RSN time courses exhibit a large amount of coactivation in all three cases, and that the modulations in their activity are closely linked to global dynamics of the underlying BOLD signal. We find that many properties of the observed fluctuations in FC and BOLD, including their ranges and their correlations amongst each other, are explained by fluctuations around the average FC structure. However, we also encounter interesting characteristics that are not explained in this way. In particular, we find that the brain spends more time in the peaks and troughs of modulations than can be expected from stationary dynamics.

Download data

  • Downloaded 581 times
  • Download rankings, all-time:
    • Site-wide: 14,422 out of 57,529
    • In neuroscience: 2,353 out of 10,118
  • Year to date:
    • Site-wide: 36,621 out of 57,529
  • Since beginning of last month:
    • Site-wide: 27,238 out of 57,529

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News