Rxivist logo

Lysosome Lipid Signaling from the Periphery to Neurons Regulates Longevity

By Marzia Savini, Jonathon Daniel Duffy, Andrew Folick, Yi-Tang Lee, Pei-Wen Hu, Isaiah Neve, Feng Jin, Qinghao Zhang, Matthew Tillman, Youqiong Ye, William Mair, Jin Wang, Leng Han, Eric Ortlund, Meng Carla Wang

Posted 10 Jun 2021
bioRxiv DOI: 10.1101/2021.06.10.447794

Lysosomes are key cellular organelles that metabolize extra- and intracellular substrates. Alterations in lysosomal metabolism are implicated in aging-associated metabolic and neurodegenerative diseases. However, how lysosomal metabolism actively coordinates the metabolic and nervous systems to regulate aging remains unclear. Here, we report a fat-to-neuron lipid signaling pathway induced by lysosomal metabolism and its longevity promoting role in Caenorhabditis elegans. We discovered that lysosomal lipolysis in peripheral fat storage tissue up-regulates the neuropeptide signaling pathway in the nervous system to promote longevity. This cell-non-autonomous regulation requires the secretion from the fat storage tissue of a lipid chaperone protein LBP-3 and polyunsaturated fatty acids (PUFAs). LBP-3 binds to specific PUFAs, and acts through a nuclear hormone receptor NHR-49 and neuropeptide NLP-11 in neurons to extend lifespan. Together, these results reveal lysosomes as a signaling hub to coordinate metabolism and aging, and a lysosomal signaling mechanism that mediates inter-tissue communication to promote longevity.

Download data

  • Downloaded 419 times
  • Download rankings, all-time:
    • Site-wide: 71,817
    • In cell biology: 3,233
  • Year to date:
    • Site-wide: 9,769
  • Since beginning of last month:
    • Site-wide: 1,099

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

News