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Elevated colonic microbiota-associated paucimannosidic and truncated N-glycans in pediatric ulcerative colitis

By Henghui Li, Xu Zhang, Rui Chen, Kai Cheng, Zhibin Ning, Jianjun Li, Susan Twine, Alain Stintzi, David Mack, Daniel Figeys

Posted 28 May 2021
bioRxiv DOI: 10.1101/2021.05.27.446002

Pediatric ulcerative colitis (UC) is a distinct type of inflammatory bowel disease with severe disease activity and rapid progression, which can lead to detrimental life-long consequences. The pathogenesis of pediatric UC remains unclear, although dysbiosis of the gut microbiota has been considered an important factor. In this study, we used mass spectrometry-based glycomic approaches to examine the N-glycans that were associated with the intestinal mucosal-luminal interface microbiota cells of treatment-naive pediatric UC or control patients. We observed abundant paucimannosidic and other truncated N-glycans that were associated with the microbiota and found that the pediatric UC microbiota samples contained significantly higher levels of these atypical N-glycans compared to those of controls. This study indicates that intestinal N-glycans may be used as novel UC biomarker candidates and the aberrant metabolism of glycans by gut microbiota may be involved in the pathogenesis of UC in children.

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