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Controlling pallidal oscillations in real-time in Parkinson's disease using evoked interference deep brain stimulation (eiDBS): proof of concept in the human

By David Escobar Sanabria, Joshua E Aman, Valentina Zapata Amaya, Luke A Johnson, Hafsa Farooqi, Jing Wang, Meghan Hill, Remi Patriat, Kelly Sovell-Brown, Gregory F Molnar, David Darrow, Robert McGovern, Scott E Cooper, Noam Harel, Colum D MacKinnon, Michael C Park, Jerrold L Vitek

Posted 23 May 2021
bioRxiv DOI: 10.1101/2021.05.22.445251

Approaches to control basal ganglia neural activity in real-time are needed to clarify the causal role of 8-35 Hz ("beta band") oscillatory dynamics in the manifestation of Parkinson's disease (PD) motor signs. Here, we show that resonant beta oscillations evoked by electrical stimulation with precise amplitude and timing can be used to predictably suppress or amplify spontaneous beta band activity in the internal segment of the globus pallidus (GPi) in the human. Using this approach, referred to as closed-loop evoked interference deep brain stimulation (eiDBS), we could suppress or amplify frequency-specific (16-22 Hz) neural activity in a PD patient. Amplification of targeted oscillations led to an increase in the variance of motor tracking delays, supporting the hypothesis that pallidal beta oscillations are linked to motor performance. Our results highlight the utility of eiDBS to characterize the pathophysiology of PD and other brain conditions in the human and develop personalized neuromodulation therapies.

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