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SARS-CoV-2 Seroprevalence and Risk Factors among Convalescents in Sichuan Province, China: a retrospective cohort study

By Lijun Zhou, Cheng Li, Huiping Yang, Heng Yuan, Ming Pan, Xiuwei Cheng, Xiaoyan Su, Yuanfang Zhu, Jianan Xu, Jianxiang Tang, Xunbo Du, Huanwen Peng, Chen Xiao, Tao Huang, Deqiang Xian, Hongxiu Liao, Haozhou Wang, Wenwu Liu, Ping Zhou, Zhengdong Zhang, Juan Liu, Xianping Wu, Tao Zhang

Posted 05 May 2021
medRxiv DOI: 10.1101/2021.05.04.21256355

Objectives: To understand SARS-CoV-2 seroprevalence of convalescents and assess their the immunity. Furthermore, we intend to explore the association between antibody levels and with demographic factors. Methods: 177 COVID-19 convalescents in Sichuan Province were voluntarily participated in our study. 363 serum samples were collected from June, 2020 to November, 2020. Duration of seroprevelance in these convalescents and their demographic characteristics were described, and the risk factors to antibody levels were analysed. Results: Men had more than twice the odds of having IgM antibody positive compared with women (OR=2.419, 95% CI:[1.232, 4.751]). Participants without symptoms were nearly 0.5 times IgG seropositive than those with symptoms (OR=0.455, 95% CI: [0.220, 0.940]). People aged[&ge;]60 years were nearly 3 times IgG seropositive than those who aged < 20 years (OR=2.986, 95% CI: [1.058, 8.432]). Seroprevalence in asymptomatic declined quicker than symptomatic. Conclusions: Age and gender may affect the antibody levels and seroprevalence. Asymptomatic appeared more easier to turn to seronegative than symptomatic. Keywords: Seroprevalence; SARS-CoV-2; Risk Factors

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