Rxivist logo

Acoustically Targeted Chemogenetics for Noninvasive Control of Neural Circuits

By Jerzy O. Szablowski, Brian Lue, Audrey Lee-Gosselin, Dina Malounda, Mikhail G. Shapiro

Posted 01 Jan 2018
bioRxiv DOI: 10.1101/241406 (published DOI: 10.1038/s41551-018-0258-2)

Neurological and psychiatric diseases often involve the dysfunction of specific neural circuits in particular regions of the brain. Existing treatments, including drugs and implantable brain stimulators, aim to modulate the activity of these circuits, but are typically not cell type-specific, lack spatial targeting or require invasive procedures. Here, we introduce an approach to modulating neural circuits noninvasively with spatial, cell-type and temporal specificity. This approach, called acoustically targeted chemogenetics, or ATAC, uses transient ultrasonic opening of the blood brain barrier to transduce neurons at specific locations in the brain with virally-encoded engineered G-protein-coupled receptors, which subsequently respond to systemically administered bio-inert compounds to activate or inhibit the activity of these neurons. We demonstrate this concept in mice by using ATAC to noninvasively modify and subsequently activate or inhibit excitatory neurons within the hippocampus, showing that this enables pharmacological control of memory formation. This technology allows a brief, noninvasive procedure to make one or more specific brain regions capable of being selectively modulated using orally bioavailable compounds, thereby overcoming some of the key limitations of conventional brain therapies.

Download data

  • Downloaded 1,978 times
  • Download rankings, all-time:
    • Site-wide: 3,863 out of 92,757
    • In neuroscience: 554 out of 16,496
  • Year to date:
    • Site-wide: 29,971 out of 92,757
  • Since beginning of last month:
    • Site-wide: 41,660 out of 92,757

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)