Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection with persisting antibody responses and memory B and T cells
Kristen W Cohen,
Susanne L. Linderman,
Lindsay E. Nyhoff,
Venkata Viswanadh Edara,
Stephen C De Rosa,
Shivan N. Patel,
Maria P Lemos,
Carl W Davis,
Mohini P. Gharpure,
Kathy A. Stephens,
Veronika I Zarnitsyna,
David S Stephens,
Evan J. Anderson,
Aneesh K. Mehta,
Mehul S Suthar,
M Juliana McElrath
Posted 27 Apr 2021
medRxiv DOI: 10.1101/2021.04.19.21255739
Posted 27 Apr 2021
Ending the COVID-19 pandemic will require long-lived immunity to SARS-CoV-2. We evaluated 254 COVID-19 patients longitudinally from early infection and for eight months thereafter and found a predominant broad-based immune memory response. SARS-CoV-2 spike binding and neutralizing antibodies exhibited a bi-phasic decay with an extended half-life of >200 days suggesting the generation of longer-lived plasma cells. In addition, there was a sustained IgG+ memory B cell response, which bodes well for a rapid antibody response upon virus re-exposure. Polyfunctional virus-specific CD4+ and CD8+ T cells were also generated and maintained with an estimated half-life of 200 days. Interestingly, the CD4+ T cell response equally targeted several SARS-CoV-2 proteins, whereas the CD8+ T cell response preferentially targeted the nucleoprotein, highlighting the importance of including the nucleoprotein as a potential vaccine antigen. Taken together, these results suggest that broad and effective immunity may persist long-term in recovered COVID-19 patients.
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