Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture
By
Eva G. Alvarez,
Jonas Demeulemeester,
Clemency Jolly,
Daniel Garcia-Souto,
Paula Otero,
Ana Pequeno,
Jorge Zamora,
Marta Tojo,
Javier Temes,
Adrian Baez-Ortega,
Bernardo Rodriguez-Martin,
Yilong Li,
Ana Oitaben,
Alicia L. Bruzos,
Monica Martinez-Fernandez,
Kerstin Haase,
Martin Santamarina,
Sonia Zumalave,
Rosanna Abal,
Jorge Rodriguez-Castro,
Aitor Rodriguez-Casanova,
Angel Diaz-Lagares,
Keiran Raine,
Adam P Butler,
Atsuhi Ono,
Hiroshi Aikata,
Kazuaki Chayama,
Masaki Ueno,
Shinya Hayami,
Hiroki Yamaue,
Miguel G. Blanco,
Xavier Forns,
Carmen Rivas,
Sofia Perez-del-Pulgar,
Raul Torres-Ruiz,
Sandra Rodriguez Perales,
Urtzi Garaigorta,
Hidewaki Nakagawa,
Peter J. Campbell,
Peter Van Loo,
Jose M.C. Tubio
Posted 19 Apr 2021
bioRxiv DOI: 10.1101/2021.04.19.440412
Most cancers are characterized by the somatic acquisition 52 of genomic rearrangements during tumour evolution that eventually drive the oncogenesis. There are different mutational mechanisms causing structural variation, some of which are specific to particular cancer types. Here, using multiplatform sequencing technologies, we identify and characterize a remarkable mutational mechanism in human hepatocellular carcinoma caused by Hepatitis B virus, by which DNA molecules from the virus are inserted into the tumour genome causing dramatic changes in its configuration, including non-homologous chromosomal fusions and megabase-size telomeric deletions. This aberrant mutational process, present in at least 8% of all HCC tumours, is active early during liver cancer evolution and can provide the driver rearrangements that a cancer clone requires to survive and grow.
Download data
- Downloaded 596 times
- Download rankings, all-time:
- Site-wide: 84,548
- In cancer biology: 2,473
- Year to date:
- Site-wide: 187,131
- Since beginning of last month:
- Site-wide: 135,850
Altmetric data
Downloads over time
Distribution of downloads per paper, site-wide
PanLingua
News
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!